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山东大学陈子江教授课题组在阻断线粒体遗传病研究领域取得突破性进展
山东大学 陈子江教授课题组 线粒体遗传病 三亲试管婴儿
2017/5/18
2017年5月12日，国际学术权威刊物自然出版集团旗下子刊《Cell Research》杂志（IF=14.812）在线发表了山东大学生殖医学研究中心陈子江教授课题组线粒体移植技术研究的新成果。线粒体移植技术，即俗称的“三亲试管婴儿”所应用的关键核心技术。陈子江教授课题组率先在人类受精卵中实施第二极体移植，可有效阻断线粒体疾病的遗传，为“三亲试管婴儿”的临床实施奠定了技术基础，标志着山东大学在该领域...
日前，世界著名出版集团爱思唯尔(Elsevier)发布了“2016年中国高被引学者”（Most Cited Chinese Researchers）榜单，我校化学学院李越湘(“能源”类榜单)、江西省医学科学院闵卫平(“医学”类榜单)、生物质转化教育部工程研究中心阮榕生(“农业和生物科学”类榜单)教授入选。在2014、2015年度，李越湘、闵卫平和阮榕生三人亦入选该榜单。“2016年中国高被引...
近日，国际首例应用“MaReCS （Mapping allele with Resolved Carrier State，等位基因映射识别胚胎平衡易位携带状态）” 成功阻断染色体平衡易位向子代传递的健康试管婴儿在郑州大学第一附属医院诞生。这一技术的研发成功和临床转化，将有望为全球数千万例平衡易位携带者家庭改写生育结局。郑州大学第一附属医院生殖医学中心孙莹璞教授团队与亿康基因陆思嘉等合作，历时近2年...
上海交通大学医学院附属上海儿童医学中心李奋教授团队开展先心病相关研究获创新成果（图）
上海儿童医学中心 教授 先心病 胎儿
2016/12/13
上海交通大学医学院附属上海儿童医学中心李奋教授领衔的“先天性左室流出道病变发病机制及个体化精准诊治的综合研究”项目近日获得2016年度华夏医学科技奖三等奖。该项目由上海儿童医学中心独立完成，课题产生多个国际、国内破突。项目主要完成人为：李奋；张海波；傅启华；赵武；董素贞；张玉奇；洪海筏；傅立军；朱铭；陈会文；郑景浩；高伟；黄美容；陈轶维；吉炜。
人们对寨卡病毒的担忧，主要源于孕妇感染寨卡病毒会造成新生儿小头症。现在，美国圣路易斯华盛顿大学和范德比特大学的研究人员发现了一种人类抗体，或可减轻人们的担忧。小鼠实验表明，该抗体可保护小鼠胎儿免受寨卡病毒侵害。这一新发现2016年11月7日在线发表于《自然》杂志上，将有助于开发新的寨卡病毒疫苗或疗法。
Growth of infants consuming whey-predominant term infant formulas with a protein content of 1.8 g/100 kcal: a multicenter pooled analysis of individual participant data
multicenter individual participant data pooled analysis low-protein infant formula breast milk infant growth probiotics prebiotics
2018/12/18
Background: High protein intake during infancy may contribute to obesity later in life in infants who are not exclusively breastfed. Lowering the protein content of infant formula so it is closer to t...
A dose-response crossover iodine balance study to determine iodine requirements in early infancy
iodine infants iodine requirement iodine balance iodine intake iodine deficiency
2018/12/13
Background: Optimal iodine intake during infancy is critical for brain development, but no estimated average requirement (EAR) is available for this age group.
Early exclusive breastfeeding is associated with longer telomeres in Latino preschool children
breastfeeding infants obesity telomere telomere length Latino
2018/12/3
Background: Telomere length (TL) is a marker of cellular aging, with the majority of lifetime attrition occurring during the first 4 y. Little is known about risk factors for telomere shortening in ch...
Predominantly nighttime feeding and weight outcomes in infants
adiposity circadian feeding infant nighttime overweight
2018/12/3
Background: The influence of circadian feeding patterns on weight outcomes has been shown in animal and human studies but not in very young children.
Predominantly nighttime feeding and weight outcomes in infants
adiposity circadian feeding infant nighttime overweight
2018/12/13
Background: The influence of circadian feeding patterns on weight outcomes has been shown in animal and human studies but not in very young children.
Vitamin D status is associated with uteroplacental dysfunction indicated by pre-eclampsia and small-for-gestational-age birth in a large prospective pregnancy cohort in Ireland with low vitamin D status
BackgroundAssociations between vitamin D and pregnancy outcomes have been inconsistent.
2018/12/13
Background: Associations between vitamin D and pregnancy outcomes have been inconsistent.
Elevations in serum anti-flagellin and anti-LPS Igs are related to growth faltering in young Tanzanian children
child growth environmental enteric dysfunction intestinal biomarkers anti-flagellin antibodies anti-LPS antibodies intestinal
2018/11/30
Background: Antibodies to LPS and flagellin have been described as indirect measures of increased gastrointestinal permeability and may be markers of environmental enteric dysfunction (EED), which is ...
Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes
fetal growth preterm birth small-size for gestational age pediatrics pregnancy birth weight 25(OH)D vitamin D
2018/11/30
Background: Maternal vitamin D deficiency during pregnancy may affect fetal outcomes.Objective: The objective of this study was to examine whether maternal 25-hydroxyvitamin D [25(OH)D] concentrations...
Abdominal adipose tissue compartments vary with ethnicity in Asian neonates: Growing Up in Singapore Toward Healthy Outcomes birth cohort study
abdominal adipose tissue compartments Asian neonates MRI ethnic differences metabolic risk birth cohort study
2018/11/30
Background: A susceptibility to metabolic diseases is associated with abdominal adipose tissue distribution and varies between ethnic groups. The distribution of abdominal adipose tissue at birth may ...