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Genetic influences on schizophrenia and subcortical brain volumes:large-scale proof of concept
schizophrenia subcortical brain volumes large-scale proof of concept
2016/5/3
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic...
Patterns of Gray Matter Abnormalities in Schizophrenia Based on an International Mega-analysis
independent component analysis schizophrenia source-based morphometry symptoms voxel-based morphometry
2015/5/5
Analyses of gray matter concentration (GMC) deficits in patients with schizophrenia (Sz) have identified robust changes throughout the cortex. We assessed the relationships between diagnosis, overall ...
A direct molecular link between the autism candidate gene RORa and the schizophrenia candidate MIR137
direct molecular link autism candidate gene RORa the schizophrenia candidate MIR137
2015/5/5
Retinoic acid-related orphan receptor alpha gene (RORa) and the microRNA MIR137 have both recently been identified as novel candidate genes for neuropsychiatric disorders. RORa encodes a ligand-depend...
No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
miR-137 TCF4 ZNF804A Genetic neuroimaging Brain volume
2015/5/5
Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we...
Hypomethylation of the Paternally Inherited LRRTM1 Promoter Linked to Schizophrenia
epigenetics parental imprint sibling pair psychosis
2015/5/5
Epigenetic effects on psychiatric traits remain relatively understudied, and it remains unclear what the sizes of individual epigenetic effects may be, or how they vary between different clinical popu...
Population-based linkage analysis of schizophrenia and bipolar case–control cohorts identifies a potential susceptibility locus on 19q13
schizophrenia segmental sharing case–control genome scan
2015/4/8
Population-based linkage analysis is a new method for analysing genomewide single nucleotide polymorphism (SNP) genotype data in case–control samples, which does not assume a common disease, common va...
TIME SKIPS AND TRALFAMADORIANS: CULTURAL SCHIZOPHRENIA AND SCIENCE FICTION IN KURT VONNEGUT’S SLAUGHTERHOUSE-FIVE AND THE SIRENS OF TITAN
Kurt Vonnegut Slaughterhouse-five The Sirens of Titan Science Fiction Cultural Schizophrenia
2015/1/8
In his novels Slaughterhouse-five and The Sirens of Titan, Kurt Vonnegut explores issues of cultural identity in technologically-advanced societies post-World War II. With the rise of globalization an...
A schizophrenia-associated HLA locus affects thalamus volume and asymmetry
Psychiatry Thalamus Hippocampus
2015/12/18
Genes of the Major Histocompatibility Complex (MHC) have recently been shown to have neuronal functions in the thalamus and hippocampus. Common genetic variants in the Human Leukocyte Antigens
(HLA) ...